Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Peroxisomes and neurologic diseases].

C Sereni1, M Paturneau-Jouas

  • 1Neurobiologie Cellulaire, Moléculaire et Clinique, INSERM U 134, CNRS UA, Hôpital de la Salpêtrière, Paris.

Revue Neurologique
|January 1, 1989
PubMed
Summary

Peroxisomes are vital organelles involved in metabolic processes. Peroxisomal disorders, ranging from single enzyme defects to multiple deficiencies, require further research for effective therapies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association of patella alta with worsening of patellofemoral osteoarthritis-related structural damage: data from the Osteoarthritis Initiative.

Osteoarthritis and cartilage·2018
Same author

Phenotype genotype analysis in 15 patients presenting a congenital myasthenic syndrome due to mutations in DOK7.

Journal of neurology·2009
Same author

The CHRNE 1293insG founder mutation is a frequent cause of congenital myasthenia in North Africa.

Neurology·2008
Same author

Tubular aggregates are from whole sarcoplasmic reticulum origin: alterations in calcium binding protein expression in mouse skeletal muscle during aging.

Neuromuscular disorders : NMD·2004
Same author

Assessing gene and cell therapies applied in striated skeletal and cardiac muscle: is there a role for nuclear magnetic resonance?

Neuromuscular disorders : NMD·2003
Same author

Rapid efficacy of highly active antiretroviral therapy in a case of HIV myelitis.

European journal of internal medicine·2002

Area of Science:

  • Cell Biology
  • Biochemistry

Context:

  • Peroxisomes are essential organelles found across species, tissues, and physiological states.
  • They play crucial roles in anabolic and catabolic pathways, including ether-lipid synthesis and beta-oxidation.
  • Microperoxisomes are specifically identified in the central nervous system and muscle tissue.

Purpose:

  • To provide a comprehensive overview of peroxisome functions and associated disorders.
  • To categorize peroxisomal disorders into those with multiple deficiencies and single enzyme defects.
  • To discuss current therapeutic approaches and diagnostic methods for peroxisomal disorders.

Summary:

  • Peroxisomes are versatile organelles involved in key metabolic processes like fatty acid oxidation and lipid synthesis.
  • Peroxisomal disorders encompass a spectrum from Zellweger syndrome to X-linked adrenoleukodystrophy, stemming from single enzyme defects or multiple functional deficiencies.
  • Current treatments are limited, involving peroxisomal inducers and dietary management, with prenatal diagnosis and genetic counseling available for some conditions.

Impact:

  • Highlights the critical role of peroxisomes in cellular metabolism and health.
  • Classifies peroxisomal disorders, aiding in understanding their genetic basis and clinical presentation.
  • Emphasizes the need for improved therapeutic strategies and diagnostic tools for peroxisomal diseases.

Related Experiment Videos