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A framework for the next generation of risk science
Daniel Krewski1, Margit Westphal, Melvin E Andersen
1McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ottawa, Ontario, Canada.
Environmental Health Perspectives
|April 15, 2014
Summary
The U.S. Environmental Protection Agency
Area of Science:
- Environmental science
- Toxicology
- Risk assessment
Background:
- The U.S. Environmental Protection Agency (EPA) launched the NexGen project in 2011.
- The project aimed to establish a new framework for next-generation risk science.
Purpose of the Study:
- To develop a new paradigm for risk science.
- To integrate advances in toxicity pathways, population health, and risk assessment methodologies.
Main Methods:
- The NexGen framework comprises three phases: problem formulation and scoping, risk assessment using new toxicity testing tools, and development of evidence-based risk management strategies.
- Incorporates a population health perspective and advanced risk assessment methodologies.
Main Results:
- The NexGen framework is structured into three phases: objectives, risk assessment, and risk management.
- Phase I focuses on problem formulation and scoping.
- Phase II utilizes new toxicity testing tools to identify pathway perturbations and advanced methodologies for risk characterization.
- Phase III involves developing evidence-based population health risk management strategies.
Conclusions:
- Case study prototypes indicate that key components of the NexGen framework are being implemented in practice.
- The NexGen framework is influencing current risk science and management approaches.
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