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Neuropathological abnormalities in developmental dysphasia.

M Cohen1, R Campbell, F Yaghmai

  • 1Department of Neurology, Medical College of Georgia, Augusta 30912.

Annals of Neurology
|June 1, 1989
PubMed
Summary
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Neuropathological examination of a child with developmental dysphasia revealed brain anomalies, including atypical plana temporale symmetry and a dysplastic frontal gyrus. These findings suggest a neurodevelopmental origin for the language disorder.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Pathology

Background:

  • Developmental dysphasia is a language disorder with potential neurodevelopmental origins.
  • Understanding brain anomalies associated with developmental dysphasia is crucial for diagnosis and treatment.

Purpose of the Study:

  • To investigate the neuropathological findings in a case of developmental dysphasia.
  • To correlate observed brain anomalies with the neurodevelopmental period of neuronal migration.

Main Methods:

  • Gross and histological examination of the brain from a 7-year-old girl with developmental dysphasia.
  • Neuropathological analysis focusing on cortical structure and symmetry.

Main Results:

  • Atypical symmetry of the plana temporale was observed.

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  • A dysplastic gyrus was identified on the inferior surface of the left frontal cortex.

    • Conclusions:

    • The identified brain anomalies are likely linked to midgestation neuronal migration disruptions.
    • These findings support a neurodevelopmental etiology for developmental dysphasia.