Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

MS: a CNS and systemic autoimmune disease.

D A Hafler, H L Weiner

    Immunology Today
    |March 1, 1989
    PubMed
    Summary
    This summary is machine-generated.

    Multiple sclerosis (MS) involves immune system abnormalities in both the central nervous system (CNS) and peripheral compartments. Research shows T-cell defects in MS patients are linked to peripheral immune responses and T-cell migration to the CNS.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Interferon regulatory factor 5 gene variants and pharmacological and clinical outcome of Interferonβ therapy in multiple sclerosis.

    Genes and immunity·2011
    Same author

    A knowledge-driven interaction analysis reveals potential neurodegenerative mechanism of multiple sclerosis susceptibility.

    Genes and immunity·2011
    Same author

    HLA B*44: protective effects in MS susceptibility and MRI outcome measures.

    Neurology·2010
    Same author

    A unique antibody gene signature is prevalent in the central nervous system of patients with multiple sclerosis.

    Journal of neuroimmunology·2010
    Same author

    A non-synonymous SNP within membrane metalloendopeptidase-like 1 (MMEL1) is associated with multiple sclerosis.

    Genes and immunity·2010
    Same author

    CTLA4Ig treatment in patients with multiple sclerosis: an open-label, phase 1 clinical trial.

    Neurology·2008

    Area of Science:

    • Neuroimmunology
    • Autoimmune Diseases

    Background:

    • Multiple sclerosis (MS) is a CNS inflammatory disease affecting white matter.
    • Immune abnormalities in MS patients extend beyond the CNS to the peripheral immune system.
    • These peripheral abnormalities include T-cell immunoregulatory defects and T- and B-cell hyperactivity.

    Purpose of the Study:

    • To review evidence linking T-cell abnormalities in MS to other autoimmune diseases.
    • To discuss the migration of activated T cells from peripheral blood to the CNS in MS.
    • To explore the impact of peripheral immunotherapy on MS disease activity.

    Main Methods:

    • Review of existing scientific literature on MS immunopathogenesis.
    • Analysis of T-cell function and immune abnormalities in MS patients.

    Related Experiment Videos

  • Examination of immunotherapy outcomes in relation to peripheral immune compartment modulation.

    • Main Results:

    • T-cell abnormalities in MS resemble those in other autoimmune conditions like lupus and rheumatoid arthritis.
    • Peripheral immunoregulatory defects in MS are associated with rapid T-cell migration to the CNS.
    • Therapies targeting the peripheral immune system demonstrate disease-modifying effects in MS.

    Conclusions:

    • The inflammatory response in the CNS during MS is closely connected to the peripheral immune compartment.
    • Peripheral immune system modulation offers a potential therapeutic strategy for MS.
    • Understanding peripheral immune involvement is crucial for managing MS.