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Related Experiment Video

Updated: May 1, 2026

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

Published on: November 15, 2013

[Not Available].

J Braun¹, B Manger

¹Rheumazentrum Ruhrgebiet, Herne und Freie Universität, Berlin, Germany.

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz

|April 15, 2014

Summary

This summary is machine-generated.

Tumor necrosis factor-alpha (TNFα) antagonists are highly effective for treating ankylosing spondylitis (AS) and psoriatic arthritis (PsA). This breakthrough therapy offers significant relief for axial and peripheral symptoms in spondyloarthritis patients.

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Last Updated: May 1, 2026

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Area of Science:

Rheumatology
Immunology
Pharmacology

Context:

Ankylosing spondylitis (AS) and psoriatic arthritis (PsA) are prevalent inflammatory rheumatic conditions within the spondyloarthritis (SpA) spectrum.
Limited therapeutic options historically constrained management of SpA.
Emerging research highlights the critical role of tumor necrosis factor-alpha (TNFα) in SpA pathogenesis.

Purpose:

To evaluate the efficacy of TNFα antagonists in treating AS and PsA.
To assess the impact of TNFα antagonists on both axial and peripheral symptoms of SpA.
To compare the effectiveness of TNFα antagonists in SpA versus rheumatoid arthritis (RA).

Summary:

Randomized controlled trials demonstrate significant efficacy of TNFα antagonists for AS and PsA.
Treatment with TNFα antagonists addresses both axial and peripheral disease manifestations effectively.
Evidence suggests TNFα antagonists may be more effective in SpA than in RA, comparable to corticosteroids in polymyalgia rheumatica.

Impact:

TNFα antagonists represent a major therapeutic advancement for rheumatic diseases, particularly SpA.
This treatment offers improved outcomes for patients with AS and PsA.
The availability of TNFα antagonists has transformed the management landscape for spondyloarthritis.