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Updated: May 1, 2026

Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice

Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice

Published on: November 16, 2011

[Endogenous hyperinsulinism: two diagnostic challenges].

Ana Pires Gonçalves¹, Fernando Baptista¹, Ema Nobre¹

¹Serviço de Endocrinologia, Diabetes e Metabolismo, Centro Hospitalar Lisboa Norte, Hospital de Santa Maria, Lisboa, Portugal.

Arquivos Brasileiros De Endocrinologia E Metabologia

|April 15, 2014

Summary

This summary is machine-generated.

Hypoglycemia in healthy adults is rare and needs investigation. High insulin and C-peptide levels suggest rare causes like endogenous hyperinsulinism, requiring specific diagnosis and treatment.

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Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT

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Area of Science:

Endocrinology
Internal Medicine

Background:

Hypoglycemia in healthy adults is uncommon, necessitating a detailed diagnostic workup.
Elevated insulin and C-peptide levels during hypoglycemic episodes are key indicators.

Observation:

Presents two cases of hypoglycemia linked to endogenous hyperinsulinism.
Highlights uncommon causes of hypoglycemia encountered in clinical practice.

Findings:

Endogenous hyperinsulinism can manifest as recurrent hypoglycemia.
Diagnostic challenges include differentiating rare causes like islet cell disease and autoimmune conditions.

Implications:

Emphasizes the importance of investigating unexplained hypoglycemia in adults.
Reviews diagnostic strategies and treatment options for hyperinsulinemic hypoglycemia.