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Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice
Published on: November 16, 2011
[Endogenous hyperinsulinism: two diagnostic challenges]
Ana Pires Gonçalves1, Fernando Baptista1, Ema Nobre1
1Serviço de Endocrinologia, Diabetes e Metabolismo, Centro Hospitalar Lisboa Norte, Hospital de Santa Maria, Lisboa, Portugal.
Abstract:
Hypoglycemia in apparently healthy adults is a rare finding in clinical practice requiring a thorough investigation of the cause. During the investigation, identification of hypoglycemia associated with inappropriately high levels of insulin and C-peptide should prompt the exclusion of rare causes of hypoglycemia, including pancreatic islet-cells disease and autoimmune hypoglycemia. In this paper, we describe two cases of hypoglycemia associated with endogenous hyperinsulinism, whose causes are uncommon in clinical practice, and review important aspects of the diagnosis and treatment of hyperinsulinemic hypoglycemia.
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