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Updated: May 1, 2026
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Isolation of Normal and Cancer-associated Fibroblasts from Fresh Tissues by Fluorescence Activated Cell Sorting FACS
Published on: January 14, 2013
35.5K
Crosstalk between fibroblasts and inflammatory cells
Sophie Van Linthout1, Kapka Miteva, Carsten Tschöpe
1Berlin-Brandenburg Center for Regenerative Therapies, Charité, University Medicine Berlin, Campus Virchow Clinic, Berlin, Germany.
Cardiovascular Research
|April 15, 2014
Summary
Fibroblasts are active immune cells influencing fibrosis. They interact with immune cells, impacting disease and heart failure, shifting from a traditional view of matrix production.
Area of Science:
- Immunology
- Cell Biology
- Pathology
Background:
- Fibroblasts traditionally viewed as quiescent extracellular matrix producers.
- Emerging evidence highlights fibroblasts as active immune system participants.
- Reciprocal interactions between fibroblasts and immune cells are crucial in disease.
Purpose of the Study:
- To review the bidirectional influence of fibroblasts and immune cells in fibrosis pathogenesis.
- To explore how immune components activate fibroblasts.
- To examine fibroblast modulation of immune cell behavior and cardiac fibroblast roles in heart failure.
Main Methods:
- Literature review of preclinical and clinical studies.
- Analysis of molecular and cellular mechanisms.
- Synthesis of current research on fibroblast-immune cell crosstalk.
Main Results:
- Fibroblasts are activated by innate and adaptive immunity components.
- Fibroblasts shape the immune microenvironment through cytokines and cellular interactions.
- Cardiac fibroblasts play a key role in inflammatory cell infiltration and heart failure progression.
Conclusions:
- Fibroblast-immune cell interactions are central to fibrosis development.
- Understanding these crosstalks offers therapeutic targets for fibrotic diseases.
- Cardiac fibroblasts are critical in orchestrating cardiac inflammation and heart failure pathogenesis.
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