Related Experiment Videos
Beta-glucuronidase activity in prostatic carcinoma and benign prostatic hyperplasia
J P Pearson1, T P Pretlow, E L Bradley
1Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106.
Cancer
|August 15, 1989
Abstract:
Beta-glucuronidase activity was extracted from prostatic carcinomas and hyperplastic prostates. It was 3.6-fold higher (P less than 0.0001) in prostatic carcinoma than in prostatic hyperplasia. Analysis for isoenzymes of prostatic beta-glucuronidase by disc-gel electrophoresis in nondenaturing polyacrylamide gels demonstrated only one form of the enzyme. Histochemically, enzymatic activity was observed almost entirely in epithelial cells in both prostatic carcinoma and benign prostatic hyperplasia.