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Intrathecal/intraventricular colistin in external ventricular device-related infections by multi-drug resistant Gram

O Bargiacchi1, A Rossati, P Car

  • 1Infectious Diseases Department, University Hospital "Maggiore della Carità", Novara, Italy, olivia.bargiacchi@gmail.com.

Infection
|April 15, 2014
PubMed

Insights

Intraventricular colistin successfully treated three cases of external ventricular drain infections caused by multidrug-resistant Gram-negative rods. This approach is a safe and effective option for central nervous system infections.

Area of Science:

  • Infectious Diseases
  • Neurosurgery
  • Pharmacology

Background:

  • External ventricular drain (EVD) placement is crucial for managing various neurosurgical conditions.
  • Infections associated with EVDs, particularly those caused by multidrug-resistant Gram-negative rods (MDR-GNRs), pose significant therapeutic challenges.
  • Limited treatment options exist for MDR-GNR central nervous system (CNS) infections.

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