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Can cycles of chills and fever resolve bipolar disorder mania?
Audun Setsaas1, Arne Einar Vaaler
1Division of Psychiatry, Department of Nidaros DPS, St Olavs University Hospital, Trondheim, Norway.
Abstract:
Treatment resistance is common in populations of patients with bipolar disorder stressing the need for new therapeutic strategies. Favourable effects of fever on mental disease have been noted throughout history. Today there is increasing evidence that immunological processes are involved in the pathophysiology of mental disorders. We present a case in which a patient with treatment resistant bipolar disorder mania seemingly recovered as a result of recurrent fever. This indicates that artificial fever might become a last resort therapy for treatment resistant mania.
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