Histoplasmosis mimicking primary lung neoplasm.

Area of Science:

• Pulmonology
• Infectious Diseases
• Radiology

Background:

• Persistent cough can be a challenging symptom to diagnose.
• Lung nodules require thorough investigation to rule out malignancy.
• Fungal infections like histoplasmosis can mimic other lung pathologies.

Observation:

• A 70-year-old male ex-smoker presented with a 5-week cough.
• Chest X-ray revealed a right lung nodular density.
• Initial clinical examination was unremarkable.

Findings:

• Extensive workup included CT-guided biopsies, bronchoscopies, and PET scans.
• Multidisciplinary team discussion was crucial for diagnosis.
• Histoplasmosis was confirmed post-lung resection.

Implications:

• Histoplasmosis should be considered in the differential diagnosis of lung nodules.
• Advanced imaging and invasive procedures are vital for accurate diagnosis.
• Prompt diagnosis and treatment are essential for managing pulmonary fungal infections.