Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Antigenic changes of complement components: relevance for the analysis of complement activation.

¹Institute of Immunology and Rheumatology, Rikshospitalet, Oslo, Norway.

Complement and Inflammation

|January 1, 1989

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Retraction Note: Rifaximin alters gut microbiota profile, but does not affect systemic inflammation - a randomized controlled trial in common variable immunodeficiency.

Scientific reports·2024

Same author

Intracellular Complement Component 3 Attenuated Ischemia-Reperfusion Injury in the Isolated Buffer-Perfused Mouse Heart and Is Associated With Improved Metabolic Homeostasis.

Frontiers in immunology·2022

Same author

Phagocytosis of live and dead Escherichia coli and Staphylococcus aureus in human whole blood is markedly reduced by combined inhibition of C5aR1 and CD14.

Molecular immunology·2019

Same author

Rifaximin alters gut microbiota profile, but does not affect systemic inflammation - a randomized controlled trial in common variable immunodeficiency.

Scientific reports·2019

Same author

Complement component 5 does not interfere with physiological hemostasis but is essential for Escherichia coli-induced coagulation accompanied by Toll-like receptor 4.

Clinical and experimental immunology·2018

Same author

Staphylococcus aureus-induced complement activation promotes tissue factor-mediated coagulation.

Journal of thrombosis and haemostasis : JTH·2018

This review highlights activation-dependent epitopes in the complement cascade. Monoclonal antibodies offer advantages for studying these epitopes and developing assays for clinical applications.

Area of Science:

Immunology
Biochemistry

Background:

The complement cascade is a critical part of the immune system.
Activation-dependent epitopes are key indicators of complement system activity.

Purpose of the Study:

To review general principles of activation-dependent epitopes in the complement cascade.
To highlight the utility of monoclonal antibodies in studying these epitopes.
To discuss the application of these antibodies in diagnostic assays.

Main Methods:

Review of existing literature on complement cascade and monoclonal antibodies.
Identification and listing of available monoclonal antibodies targeting complement epitopes.
Discussion of assay development principles for complement activation detection.

Related Experiment Videos

Main Results:

Monoclonal antibodies provide specific tools for studying activation-dependent epitopes.
A range of antibodies are available for complement research.
Reliable assays can be developed to detect complement activation at all levels.

Conclusions:

Monoclonal antibodies are invaluable for understanding complement cascade activation.
These antibodies facilitate the development of crucial diagnostic assays.
Such assays are important for studying diseases involving the complement system.