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Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

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A bubble-mediated intelligent microscale electrochemical device for single-step quantitative bioassays.

Fan Yang¹, Xiaolei Zuo, Zhenhua Li

¹Division of Physical, Biology & Bioimaging Center, Shanghai Synchrotron Radiation Facility, CAS Key Laboratory of Microscale Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China; School of Laboratory Medicine, Hubei University of Chinese Medicine, 1 Huangjia Lake West Road, Wuhan, China.

Advanced Materials (Deerfield Beach, Fla.)

|April 15, 2014

Summary

A novel intelligent microscale electrochemical device (iMED) enables rapid, multiplexed detection of tumor and infectious disease biomarkers. This breakthrough offers sensitive, one-step diagnostic capabilities in under 30 minutes.

Keywords:

bioassays electrochemistry electrodes microfluidics proteins

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Area of Science:

Biomedical Engineering
Analytical Chemistry
Molecular Diagnostics

Background:

Accurate and rapid detection of disease biomarkers is crucial for timely diagnosis and treatment.
Current methods for multiplexed biomarker detection can be time-consuming and complex.
There is a need for integrated, user-friendly devices for point-of-care diagnostics.

Purpose of the Study:

To develop an intelligent microscale electrochemical device (iMED) for one-step, quantitative, and multiplexed biomarker detection.
To adapt "plug-in-cartridge" technology for use with screen-printed electrodes (SPEs) in electrochemical devices.
To demonstrate the iMED's capability in detecting biomarkers for infectious diseases and tumors.

Main Methods:

Development of an intelligent microscale electrochemical device (iMED).
Integration of "plug-in-cartridge" technology with screen-printed electrodes (SPEs).
Electrochemical detection of specific biomarkers associated with two tumor types and one infectious disease.

Main Results:

The iMED achieved quantitative and multiplexed detection of multiple biomarkers.
Biomarkers were detected at clinically relevant sub-ng/mL levels.
The entire detection process was completed in less than 30 minutes.

Conclusions:

The developed iMED offers a rapid, sensitive, and efficient platform for diagnosing infectious diseases and tumors.
The "plug-in-cartridge" SPE adaptation facilitates a user-friendly, one-step diagnostic approach.
This technology holds significant potential for advancing point-of-care diagnostics.