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Keratinizing corneal intraepithelial neoplasia
H H Brown1, B J Glasgow, G N Holland
1Department of Pathology, UCLA Center for the Health Sciences 90024.
Cornea
|September 1, 1989
Summary
Corneal intraepithelial neoplasia (CIN) can present atypically. This case highlights a rare corneal-limited CIN misdiagnosed as a calcific scar due to its white plaque appearance.
Area of Science:
- Ophthalmology
- Oncology
- Pathology
Background:
- Corneal intraepithelial neoplasia (CIN) encompasses a spectrum of epithelial dysplasia to carcinoma in situ.
- CIN lesions typically involve the limbus or conjunctiva; isolated corneal involvement is uncommon.
Observation:
- A rare case of CIN was observed, presenting clinically as a white plaque on the cornea.
- This unusual presentation led to a misdiagnosis of a calcific scar.
Findings:
- Histopathologic examination confirmed intraepithelial neoplasia limited to the cornea.
- Marked hyperkeratosis was identified as the cause of the corneal opacification.
Implications:
- This case underscores the importance of considering CIN in atypical corneal presentations.
- Accurate diagnosis of corneal neoplasia requires thorough histopathologic evaluation.
- Understanding rare clinical variants of CIN is crucial for appropriate patient management.