Inhibition of human immunodeficiency virus-associated reverse transcriptase by aminoacridines

A semi-synthetic bleomycin analogue and its DNA binding moiety, an alkylamino-2-methoxy-6-chloroacridine, have been found to inhibit human immunodeficiency virus-associated reverse transcriptase. The authors have synthesized various new alkylaminoacridine derivatives. Alkylaminoacridines with basic functional groups showed the enzyme inhibitory activity with less cytotoxicity.