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Recovery from stress - a cell cycle perspective.

Elahe Radmaneshfar1, Marco Thiel1

  • 1Institute for Complex Systems and Mathematical Biology, SUPA, University of Aberdeen, Aberdeen, AB24 3UE, UK.

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Summary

This study uses a Boolean model to show how osmotic stress halts budding yeast cell cycle progression at specific arrest points. Cells can recover after stress removal, and stress can even induce division in previously arrested cells.

Keywords:
Boolean networkalpha factorcell cycleosmotic stressstate transitionstress response

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Area of Science:

  • Cell Biology
  • Systems Biology
  • Computational Biology

Background:

  • Budding yeast (Saccharomyces cerevisiae) is a model organism for studying cell cycle regulation.
  • Osmotic and pheromone stress are critical environmental factors influencing cell cycle progression.
  • Understanding stress-induced cell cycle arrest and recovery is vital for cell biology.

Purpose of the Study:

  • To develop a Boolean model for exploring budding yeast cell cycle dynamics under osmotic and pheromone stress.
  • To predict cell cycle arrest points and recovery mechanisms.
  • To evaluate pheromone-based synchronization methods for studying stress responses.

Main Methods:

  • Development of a Boolean model to simulate cell cycle dynamics.
  • Analysis of model predictions for osmotic and pheromone stress responses.
  • Investigation of cell state transitions and recovery post-stress.

Main Results:

  • Osmotic stress halts cell cycle progression at one of four predicted arrest points, dependent on the cell's state at stress onset.
  • Cells can resume cell cycle progression after the removal of osmotic stress.
  • Pheromone-based cell cycle synchronization is unsuitable for studying specific osmotic stress arrest points.
  • Osmotic stress can induce division in previously arrested ('frozen') cells by re-engaging them with the cell cycle trajectory.

Conclusions:

  • The Boolean model accurately represents budding yeast cell cycle responses to osmotic and pheromone stress.
  • Cell cycle arrest and recovery are state-dependent processes influenced by stress type and duration.
  • The findings provide insights into cell cycle plasticity and potential therapeutic targets for stress-related cellular dysfunction.