Related Experiment Video
Updated: May 1, 2026
10:19
Studying the Effects of Matrix Stiffness on Cellular Function using Acrylamide-based Hydrogels
Published on: August 10, 2010
21.8K
The Effect of Gynostemma pentaphyllum Extract on Mouse Dermal Fibroblasts
Sara Nadia Lobo1, Yu Qing Qi1, Quan Zhong Liu1
1Department of Dermatology, Tianjin Medical University General Hospital, International Students' Building, Tianjin Medical University, Qixiangtai Road, No. 22, Heping District, Tianjin 300070, China.
ISRN Dermatology
|April 15, 2014
Summary
Gynostemma pentaphyllum extract significantly prolonged the viability of mouse dermal fibroblasts exposed to oxidative stress from ultraviolet C light. This suggests potential benefits for combating skin aging.
Area of Science:
- Dermatology
- Cell Biology
- Phytochemistry
Background:
- Oxidative stress contributes to dermal aging.
- Gynostemma pentaphyllum exhibits antioxidant properties.
- Research is needed to validate its effects on skin cells.
Purpose of the Study:
- To investigate the protective effects of Gynostemma pentaphyllum extract on mouse dermal fibroblasts.
- To assess the extract's ability to counteract oxidative stress.
Main Methods:
- Preparation of Gynostemma pentaphyllum extract.
- Culture of mouse dermal fibroblasts.
- Induction of oxidative stress using ultraviolet C (UVC) light.
- Microscopic assessment of cell viability and statistical analysis using SPSS.
Main Results:
- A strong positive correlation was observed between Gynostemma pentaphyllum concentration and cell viability duration (rs=1, P < 0.01).
- High statistical significance confirmed the protective effect.
- Cell viability trials also showed strong positive correlations (rs=0.988-1, P < 0.01).
Conclusions:
- Gynostemma pentaphyllum extract enhances the survival of dermal fibroblasts under UVC-induced oxidative stress.
- The findings indicate potential applications of this extract in mitigating dermal aging processes.
