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A Murine Model of Group B Streptococcus Vaginal Colonization

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Published on: November 16, 2016

Streptococcus gallolyticus subsp. pasteurianus meningitis in an infant.

Yoshiko Takahashi¹, Naruhiko Ishiwada, Junko Tanaka

¹Department of Pediatrics, Teikyo University Chiba Medical Center, Chiba, Japan; Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japan.

Pediatrics International : Official Journal of the Japan Pediatric Society

|April 16, 2014

Summary

A rare case of infant meningitis caused by Streptococcus gallolyticus subsp. pasteurianus (formerly S. bovis biotype II/2) was reported. The infection, originating from the intestinal tract, highlights the need for further research into its pathogenesis.

Keywords:

Streptococcus bovis Streptococcus gallolyticus subsp. pasteurianus infant meningitis pulsed-field gel electrophoresis

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Area of Science:

Microbiology
Pediatric Infectious Diseases
Clinical Case Reports

Background:

Streptococcus gallolyticus subsp. pasteurianus, previously known as S. bovis biotype II/2, is a rare cause of neonatal sepsis and meningitis.
Limited reports exist on meningitis caused by this specific subspecies following its taxonomic reclassification.
The pathogenesis of late-onset meningitis due to S. gallolyticus subsp. pasteurianus in infants remains poorly understood.

Observation:

A case of meningitis in a 5-week-old infant presenting with preceding diarrhea is described.
S. bovis biotype II/2 was isolated from the infant's blood, cerebrospinal fluid, and stool samples.
16S rRNA gene sequencing confirmed the isolate as S. gallolyticus subsp. pasteurianus.

Findings:

Pulsed-field gel electrophoresis revealed identical profiles for isolates from all three sample types (blood, CSF, stool).
This genetic similarity strongly suggests a common source of infection.
The intestinal tract is implicated as the likely origin of the invasive S. gallolyticus subsp. pasteurianus infection.

Implications:

This case underscores the potential for S. gallolyticus subsp. pasteurianus to cause severe infections like meningitis in infants.
It highlights the importance of considering the intestinal tract as a reservoir for such infections.
Further research is warranted to elucidate the specific mechanisms and risk factors contributing to S. gallolyticus subsp. pasteurianus meningitis in neonates and infants.