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Updated: May 1, 2026
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A Simplified Technique for Producing an Ischemic Wound Model
Published on: May 2, 2012
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Hyperbaric oxygen, vasculogenic stem cells, and wound healing.
Katina M Fosen1, Stephen R Thom
11 Department of Emergency Medicine, Institute for Environmental Medicine, University of Pennsylvania Medical Center , Philadelphia, Pennsylvania.
Antioxidants & Redox Signaling
|April 16, 2014
Summary
Oxidative stress, particularly from hyperoxia, positively impacts wound healing by influencing stem cell function and recruitment. This review re-frames wound healing stages to better understand these critical cellular and biochemical interactions.
Area of Science:
- Biomedical Science
- Cell Biology
- Wound Healing Research
Background:
- Reviews the impact of hyperoxia on vasculogenic stem cells and wound healing.
- Highlights the role of oxidative stress in stem cell mobilization and function.
Purpose of the Study:
- To examine the influence of hyperoxia on vasculogenic stem cells.
- To explore the multifaceted role of oxidative stress in wound healing processes.
Main Methods:
- Literature review focusing on hyperoxia and oxidative stress in wound healing.
- Analysis of cell signaling events influenced by hyperoxia.
- Re-conceptualization of wound healing stages.
Main Results:
- Oxidative stress positively influences various cells crucial for wound healing.
- Hyperoxia affects cell signaling, impacting cell recruitment and gene regulation.
- A new perspective organizes wound healing as overlapping waves of reactive oxygen species, lactate, and nitric oxide.
Conclusions:
- An alternative view of wound healing stages simplifies recognizing oxidative stress's impact.
- Focuses on mechanistic events, cellular interplay, and biochemical processes.
- Identifies areas for future research in oxidative stress and wound healing.
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