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Population-based study of esophageal and small intestinal atresia/stenosis

Daijiro Takahashi1,2, Takehiko Hiroma1, Shigeru Takamizawa3

  • 1Division of Neonatology, Nagano Children's Hospital, Nagano, Japan.

Pediatrics International : Official Journal of the Japan Pediatric Society
|April 16, 2014
PubMed

Insights

The prevalence of esophageal and small intestinal atresia/stenosis has significantly increased in Nagano, Japan. Prenatal diagnosis of esophageal atresia/stenosis is linked to more anomalies, especially chromosomal ones.

Area of Science:

  • Pediatric Surgery
  • Medical Genetics
  • Epidemiology

Background:

  • Esophageal atresia/stenosis and small intestinal atresia/stenosis are congenital conditions requiring surgical intervention.
  • Understanding their prevalence and associated factors is crucial for public health and clinical management.

Purpose of the Study:

  • To determine the prevalence of esophageal atresia/stenosis and small intestinal atresia/stenosis in Nagano, Japan.
  • To investigate associated anomalies, prenatal diagnosis rates, and survival outcomes.
  • To analyze trends in prevalence over time.

Main Methods:

  • A population-based cohort study was conducted from 1993 to 2011.
  • Statistical analyses included Mann-Whitney, chi-squared, and Kruskal-Wallis tests.
  • Prevalence rates were calculated per 10,000 births.

Main Results:

  • Prevalences were 1.97 for esophageal atresia/stenosis and 2.23 for small intestinal atresia/stenosis per 10,000 births.
  • Significant increases in prevalence were observed for both conditions from 1993-2001 to 2002-2011.
  • Duodenal atresia/stenosis showed a strong association with chromosomal anomalies, particularly trisomy 21 (55%).

Conclusions:

  • The incidence of esophageal and small intestinal atresia/stenosis has risen significantly between the two study periods.
  • Prenatally diagnosed esophageal atresia/stenosis is more frequently associated with multiple anomalies, including chromosomal abnormalities, than other small intestinal atresias/stenoses.
Abstract

Keywords:
esophageal atresia/stenosispopulation-based studysmall intestinal atresia/stenosis

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