Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Disorders01:29

Bone Disorders

8.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
8.0K
Bone Remodeling01:40

Bone Remodeling

34.4K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
34.4K
Fractures: Bone Repair01:27

Fractures: Bone Repair

5.8K
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
5.8K
Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

16.1K
Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
16.1K
Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

14.6K
Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
14.6K
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

9.2K
9.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mid-term outcomes of mobile-bearing lateral unicompartmental knee arthroplasty.

The Knee·2018
Same author

Clinically apparent adverse reactions to intra-wound vancomycin powder in early onset scoliosis are rare.

Journal of children's orthopaedics·2017
Same author

[Response to the letter to the editor from SEOP as regards the SEIP-SERPE-SEOP consensus document on the treatment of uncomplicated acute osteomyelitis and septic arthritis].

Anales de pediatria (Barcelona, Spain : 2003)·2015
Same author

[SEIP-SERPE-SEOP Consensus document on the treatment of uncomplicated acute osteomyelitis and septic arthritis].

Anales de pediatria (Barcelona, Spain : 2003)·2014
Same author

[SEIP-SERPE-SEOP Consensus Document on aetiopathogenesis and diagnosis of uncomplicated acute osteomyelitis and septic arthritis].

Anales de pediatria (Barcelona, Spain : 2003)·2014
Same author

[Early onset scoliosis. What are the options?].

Revista espanola de cirugia ortopedica y traumatologia·2013

Related Experiment Video

Updated: May 1, 2026

Culturing and Measuring Fetal and Newborn Murine Long Bones
06:58

Culturing and Measuring Fetal and Newborn Murine Long Bones

Published on: April 26, 2019

7.7K

[Advances in bone dysplasias].

E Borrego1, D M Farrington1, F J Downey1

  • 1Servicio de Traumatología Infantil, Hospitales Universitarios Virgen del Rocío, Sevilla, España.

Revista Espanola De Cirugia Ortopedica Y Traumatologia
|April 16, 2014
PubMed
Summary
This summary is machine-generated.

Bone dysplasias affect 1 in 1,000 people. Early diagnosis and management of conditions like achondroplasia are crucial for improving patient quality of life, as cures are unavailable.

Keywords:
AchondroplasiaAcondroplasiaBone dysplasiasDisplasia epifisaria múltipleDisplasia espondiloepifisariaDisplasias óseasMultiple epiphyseal dysplasiaOsteogenesis imperfectaOsteogénesis imperfectaSpondyloepiphyseal dysplasia

More Related Videos

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
07:12

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Published on: September 28, 2017

7.4K
Tricolor Transgenic Murine Model for Studying Growth Plate Injury
07:58

Tricolor Transgenic Murine Model for Studying Growth Plate Injury

Published on: September 6, 2024

1.4K

Related Experiment Videos

Last Updated: May 1, 2026

Culturing and Measuring Fetal and Newborn Murine Long Bones
06:58

Culturing and Measuring Fetal and Newborn Murine Long Bones

Published on: April 26, 2019

7.7K
Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
07:12

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Published on: September 28, 2017

7.4K
Tricolor Transgenic Murine Model for Studying Growth Plate Injury
07:58

Tricolor Transgenic Murine Model for Studying Growth Plate Injury

Published on: September 6, 2024

1.4K

Area of Science:

  • Orthopaedic surgery
  • Genetics
  • Pediatrics

Context:

  • Bone dysplasias are a group of skeletal disorders with a prevalence of approximately 1 in 1,000 live births.
  • These conditions present unique challenges for orthopaedic surgeons throughout their careers.
  • Understanding the genetic basis and clinical manifestations is essential for effective patient care.

Purpose:

  • To provide a comprehensive review of bone dysplasias, focusing on common and significant types.
  • To detail the fundamental features of key skeletal dysplasias, including achondroplasia, multiple epiphyseal dysplasia, spondyloepiphyseal dysplasia, and osteogenesis imperfecta.
  • To highlight the latest therapeutic advances and management strategies for these conditions.

Summary:

  • This review covers the general aspects of bone dysplasias and specifically examines achondroplasia, multiple epiphyseal dysplasia, spondyloepiphyseal dysplasia, and osteogenesis imperfecta.
  • It details their core characteristics and discusses recent developments in treatment.
  • The paper emphasizes that while cures are not available, early diagnosis and tailored management are vital.

Impact:

  • Early and accurate diagnosis of bone dysplasias enables timely intervention and management.
  • Appropriate therapeutic strategies can significantly improve the quality of life for affected individuals.
  • This review serves as a valuable resource for clinicians managing patients with skeletal dysplasias.