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Sodium fluorescein in skull base meningiomas: a technical note
Carlos Eduardo da Silva1, Vinicius Duval da Silva2, Jefferson Luis Braga da Silva3
1Department of Neurosurgery and Skull Base Surgery, ICBC - Instituto de Cirurgia da Base do Crânio, Hospital Ernesto Dornelles, Porto Alegre, RS, Brazil.
Clinical Neurology and Neurosurgery
|April 16, 2014
Summary
Sodium fluorescein (SF) safely and effectively enhances skull base meningiomas during surgery. This dye shows strong positive enhancement in all tumor types, offering a promising tool for neurosurgeons.
Area of Science:
- Neurosurgery
- Oncology
- Medical Imaging
Background:
- Skull base meningiomas pose significant surgical challenges due to proximity to critical neurovascular structures.
- Accurate tumor delineation is crucial for complete resection and minimizing neurological deficits.
Purpose of the Study:
- To evaluate the trans-operative utility of sodium fluorescein (SF) for enhancing skull base meningiomas.
- To quantitatively analyze the pigmentation of meningiomas using digital imaging after SF administration.
Main Methods:
- A prospective, within-subjects study involving twelve patients with skull base meningiomas.
- Digital images were captured before and after SF injection under surgical microscopy.
- Image analysis software quantified SF wavelengths to assess tumor enhancement.
Main Results:
- Sodium fluorescein (SF) demonstrated strong positive enhancement in all tested skull base meningiomas.
- Tumor types included cavernous sinus, olfactory groove, petroclival, tuberculum sellae, sphenoid wing, anterior clinoid, and temporal floor meningiomas.
Conclusions:
- Sodium fluorescein (SF) is a safe, readily available, and low-cost dye with potential for enhancing skull base meningiomas during surgery.
- Further research is warranted to explore the full applications of SF in meningioma resection.
