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Related Experiment Video

Updated: May 1, 2026

Gene Transfer for Ischemic Heart Failure in a Preclinical Model
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Lipotransfer: the potential from bench to bedside.

Ilaria Tocco1, Alan David Widgerow, Shadi Lalezari

  • 1From the *Aesthetic and Plastic Surgery Institute, University of California, Irvine, CA; †Clinic of Plastic Surgery, University of Padova, Italy; and ‡Laboratory for Tissue Engineering & Regenerative Medicine, University of California, Irvine, CA.

Annals of Plastic Surgery
|April 16, 2014
PubMed
Summary
This summary is machine-generated.

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Micro/Nanobubble-Assisted Lipotransfer: In Vivo Evidence of Improved Graft Outcomes.

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Autologous fat grafting is popular for tissue repair but lacks a standard protocol, leading to variable survival rates. Recent techniques show promise for improving fat graft viability, though more evidence is needed.

Area of Science:

  • Plastic Surgery
  • Regenerative Medicine
  • Biomaterials Science

Background:

  • Autologous fat grafting is widely used by plastic surgeons for tissue augmentation and reconstruction.
  • Significant variability in fat grafting techniques exists, resulting in inconsistent graft survival rates (40-80%).
  • A standardized protocol for fat grafting has not yet been established.

Purpose of the Study:

  • To review current literature on fat grafting techniques and their impact on graft viability.
  • To explore recent advancements and proposed methods for improving long-term fat graft survival.
  • To discuss technical choices in lipotransfer in light of emerging evidence and regulatory considerations.

Main Methods:

  • Review of current scientific literature on autologous fat grafting.

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  • Analysis of bench approaches and empirical evidence for fat graft viability.
  • Discussion of variations in harvesting, delivery, and enrichment techniques.

    • Main Results:

    • Reported fat graft survivability varies widely (40-80%) due to technical inconsistencies.
    • Emerging techniques show promise for enhancing long-term fat graft viability.
    • Current literature offers evidence for optimal techniques in specific clinical situations, pending further validation.

    Conclusions:

    • Standardization of fat grafting protocols remains a challenge.
    • Ongoing research and new techniques are advancing the field of fat grafting.
    • Informed technical decisions in lipotransfer are becoming more feasible based on recent studies.