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Effects of paroxetine on cutaneous wound healing in healthy and diabetic rats
Esra Pancar Yuksel1, Fatih Ilkaya, Levent Yildiz
1Esra Pancar Yuksel, MD, is Assistant Professor of Dermatology at the Department of Dermatology, Faculty of Medicine, Ondokuz Mayis University, Samson, Turkey. Fatih Ilkaya, MD, is Assistant Professor of Pharmacology at the Department of Pharmacology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey. Levent Yildiz, MD, is Professor of Pathology at the Department of Pathology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey. Fatma Aydin, MD, and Nilgun Senturk, MD, are Professors of Dermatology at the Department of Dermatology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey. Hilal Denizli, MD, is a Resident in Dermatology at the Department of Dermatology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey. Tayyar Canturk, MD, and Ahmet Yasar Turanli, MD, are Professors of Dermatology at the Department of Dermatology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.
Objective:
The aim of this study was to evaluate the histologic effects of acute paroxetine administration on wound healing in healthy and streptozotocin-induced diabetic rats.
Design:
This study has a randomized controlled experimental design.
Setting:
Healthy (n = 32) and diabetic (n = 32) rats were further divided into 2 groups of saline or paroxetine administration.
Participants:
Sixty-four male Sprague-Dawley rats were used in this study.
Interventions:
Paroxetine was injected intraperitoneally every day. Full-thickness excision wounds were created with a 4-mm dermal punch on the back of all rats. The healing wound area was removed with a 6-mm dermal punch at postwounding days 1, 3, 7, and 14.
Main Outcome Measures:
Polymorphonuclear leukocyte, mononuclear inflammatory cell, fibroblast, and blood vessel counts and epithelialization were evaluated under light microscope.
Main Results:
There was no statistically significant difference observed in the polymorphonuclear leukocyte, mononuclear inflammatory cell, and blood vessel counts in the healthy and diabetic rats with and without paroxetine administration. The number of fibroblasts was significantly higher at postwounding day 14 of the paroxetine-administered healthy rats compared with the saline-administered healthy rats (P = .04). However, the number of fibroblasts did not show any difference by paroxetine administration in the diabetic rats. There was no statistically significant difference in epithelialization regarding all the postwounding days, but complete epithelialization was observed in all rats on postwounding day 14 in the healthy and paroxetine-administered group.
Conclusion:
Short-term paroxetine administration may enhance cutaneous wound healing by increasing the number of fibroblasts and causing better epithelialization over time in healthy rats but not in diabetic rats.
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