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Updated: May 1, 2026

Isolation and Culture of Primary Mouse Keratinocytes from Neonatal and Adult Mouse Skin
Published on: July 14, 2017
Cytokine regulation during epidermal differentiation and barrier formation
Atsunari Tsuchisaka1, Minao Furumura1, Takashi Hashimoto1
1Department of Dermatology, Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology, Kurume, Japan.
Abstract:
The role of structural components and cell adhesion molecules in the epidermis has not been fully studied in terms of the pathophysiology of atopic dermatitis (AD). In this issue, Omori-Miyake et al. (2014) report that IL-4 and IL-13, which are Th2 cytokines, downregulate the expression of keratins and desmosomal cadherins in a STAT6-dependent manner, leading to keratinocyte fragility in the face of mechanical stress. Th2 cytokine-induced instability of the epidermis may be considered to be one of the pathogenic mechanisms that have roles in AD.
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