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Related Experiment Video

Updated: May 1, 2026

Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking

Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking

Published on: September 26, 2019

Thyroid status and cognitive function in euthyroid patients with early Parkinson's disease.

Seong-Min Choi¹, Byeong C Kim, Kang-Ho Choi

¹Department of Neurology, Chonnam National University Hwasun Hospital, Gwangju, South Korea.

Dementia and Geriatric Cognitive Disorders

|April 16, 2014

Summary

Thyroid hormone levels, specifically free thyroxine (fT4), are linked to cognitive function in early Parkinson's disease (PD). Higher fT4 may indicate poorer executive function in euthyroid PD patients.

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Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

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Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking

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Published on: September 26, 2019

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Published on: July 24, 2019

Area of Science:

Neurology
Endocrinology
Cognitive Science

Background:

Thyroid hormone (TH) alterations are implicated in mild cognitive impairment (MCI) and dementia.
Cognitive deficits are prevalent in Parkinson's disease (PD).

Purpose of the Study:

To examine the relationship between normal variations in thyroid function and cognitive function in early PD patients without dementia.

Main Methods:

Eighty-four euthyroid early PD patients were assessed for thyroid status (TSH, tT3, fT4) and cognitive function via comprehensive neuropsychological tests.
Compared thyroid hormone levels and cognitive performance between PD patients with and without MCI.

Main Results:

No significant differences in TH levels between PD patients with and without MCI.
Free thyroxine (fT4) levels showed an inverse association with Mini-Mental State Examination (MMSE) scores and tests of attention, visuospatial, and executive function.
Multiple regression analyses confirmed significant associations between fT4 concentrations and executive function and MMSE scores, after controlling for covariates.

Conclusions:

A relationship exists between thyroid status and cognitive function in euthyroid early PD patients.
Higher fT4 concentrations are associated with poorer executive function performance in this cohort.