[Characteristics of C3b-dependent neutrophil adhesion in man]
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The ability of polysaccharide granules to activate the complement by covalently fixing C3b-factor and thus interact with the cells carrying C3b-receptors on the cytoplasmic membrane has been used to assess the neutrophil C3b-receptor function. Optimal conditions of the reaction have been selected. The range of C3b-mediated reactions has been 30-60% in the majority of healthy donors. The technique is easily reproducible, simple, and stable, it may be useful for clinical monitoring.
The ability of polysaccharide granules to activate the complement by covalently fixing C3b-factor and thus interact with the cells carrying C3b-receptors on the cytoplasmic membrane has been used to assess the neutrophil C3b-receptor function. Optimal conditions of the reaction have been selected. The range of C3b-mediated reactions has been 30-60% in the majority of healthy donors. The technique is easily reproducible, simple, and stable, it may be useful for clinical monitoring.