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Updated: May 1, 2026

A Cognitive Fusion-guided Prostate Biopsy Using Multiparametric Magnetic Resonance Imaging and Transrectal Ultrasound
Published on: March 21, 2025
Multiparametric magnetic resonance imaging of the prostate aids detect lesion progression
Linda M Johnson1, Jason T Rothwax, Baris Turkbey
1*From the Molecular Pharmacology Section, Medical Oncology Branch, and †Molecular Imaging Program, National Cancer Institute, Bethesda, MD; ‡Urologic Oncology Branch, NCI, NIH, Bethesda, MD; §Center for Interventional Oncology, Radiology and Imaging Sciences CC, NIH, Bethesda, MD; ∥Clinical Pharmacology Program, Center for Cancer Research, National Cancer Institute, Bethesda, MD; and ¶Laboratory of Pathology, NCI, NIH, Bethesda, MD.
Abstract:
Multiparametric magnetic resonance imaging (MRI) provides an accurate anatomical assessment of the tumor and its local staging. Herein, we report a case of intermediate-risk prostatic adenocarcinoma, initially followed on active surveillance, which upgraded from Gleason 7 (3 + 4) to Gleason 8 (4 + 4) on transrectal ultrasound/MRI fusion biopsy after progression of MR spectroscopic findings and review of the role of multiparametric MRI in the follow-up of patients with prostate cancer undergoing active surveillance.
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