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Population differences concerning TNF-α gene polymorphisms in gastric carcinogenesis based on meta-analysis
Theodoros Rokkas1, Panos Sechopoulos1, Dimitrios Pistiolas1
1Gastroenterology Clinic, Henry Dunant Hospital, Athens, Greece.
Annals of Gastroenterology
|April 16, 2014
Summary
This meta-analysis found that tumor necrosis factor-alpha (TNF-α) gene polymorphisms, specifically TNF-α-308 G/G and A/A genotypes, are linked to an increased gastric cancer risk. The G/G genotype showed a significant association in Asian populations.
Area of Science:
- Genetics
- Oncology
- Immunology
Background:
- Gastric cancer risk is influenced by genetic factors, including polymorphisms in genes like interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-α).
- Previous meta-analyses have explored population differences in IL-1 gene polymorphisms related to gastric carcinogenesis.
- TNF-α, a pro-inflammatory cytokine, is a candidate gene for its potential role in gastric cancer development.
Purpose of the Study:
- To systematically review and meta-analyze studies on the association between TNF-α gene polymorphisms (TNF-α-238 and TNF-α-308) and gastric carcinogenesis.
- To investigate population differences in the role of TNF-α gene polymorphisms in gastric cancer risk.
Main Methods:
- Extensive literature search of English-language human studies up to May 2013.
- Pooled estimates of odds ratios (OR) with 95% confidence intervals (CI) were calculated using a random-effects model.
- Heterogeneity and publication bias were assessed using Cochran Q test, funnel plots, and adjusted rank correlation test.
Main Results:
- Seventeen studies examined TNF-α-238 and TNF-α-308 genotypes (G/G, G/A, A/A) in gastric cancer patients and controls.
- Overall, TNF-α-308 G/G (OR=0.837, P=0.029) and A/A (OR=1.430, P=0.018) genotypes were associated with statistically significant altered gastric cancer risk.
- Subgroup analysis revealed a significant association for the TNF-α-308 G/G genotype specifically in Asian populations (OR=0.774, P=0.036).
Conclusions:
- The meta-analysis indicates an overall statistically significant increased risk of gastric cancer associated with TNF-α-308 G/G and A/A genotypes.
- Significant associations for the TNF-α-308 G/G genotype were observed in Asians, but not in Caucasians or Hispanics.
- These findings highlight the role of specific TNF-α gene polymorphisms in gastric carcinogenesis, with variations across different ethnic groups.
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