Related Experiment Video
Updated: May 1, 2026
06:53
Cell Population Analyses During Skin Carcinogenesis
Published on: August 21, 2013
15.5K
Basal cell carcinoma: an evidence-based treatment update
Charlotte M Clark1, Megan Furniss, Julian M Mackay-Wiggan
1Department of Dermatology, Columbia University Medical Center, New York, NY, 10032, USA.
American Journal of Clinical Dermatology
|April 16, 2014
Summary
Surgical excision is the standard for basal cell carcinoma (BCC), but treatments like photodynamic therapy, cryotherapy, imiquimod, and 5-FU are effective for low-risk lesions. Radiotherapy is an option for older patients, while new inhibitors show promise for advanced BCC.
Area of Science:
- Dermatology
- Oncology
- Surgical Oncology
Background:
- Basal cell carcinoma (BCC) is the most prevalent form of skin cancer.
- Surgical excision is the current standard treatment for BCC.
- Alternative treatment modalities are available for BCC management.
Purpose of the Study:
- To analyze current evidence on BCC treatments.
- Identify treatments with the lowest recurrence rates.
- Determine treatments offering the best cosmetic outcomes.
Main Methods:
- Searched major databases (PubMed, MEDLINE, Cochrane) from 1946 to August 2013.
- Included randomized controlled trials, systematic reviews, and comparative studies.
- Reviewed 40 selected studies out of 615 potential articles.
Main Results:
- Surgical methods, including Mohs surgery for high-risk lesions, remain the gold standard.
- Photodynamic therapy (PDT), cryotherapy, topical imiquimod, and 5-FU are suitable alternatives for low-risk BCC.
- Radiotherapy is a viable option for older patients; hedgehog pathway inhibitors show promise for advanced BCC.
Conclusions:
- Surgical treatments are the primary standard for BCC, with Mohs surgery for high-risk cases.
- PDT, cryotherapy, topical imiquimod, and 5-FU are effective alternatives for selected low-risk BCC.
- Further research is needed to establish optimal use and long-term efficacy of various BCC treatments.
More Related Videos
07:29Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
11.4K
09:37Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
Published on: August 18, 2022
2.8K
Related Concept Videos
01:30Skin Cancer
5.2K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
5.2K
01:12Renewal of Skin Epidermal Stem Cells
2.4K
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
2.4K
01:03Basal Lamina are the Specialized Form of ECM
3.1K
The basal lamina is a thin extracellular layer that lies underneath the cells and separates them from other tissues. The three layers of the basal lamina are lamina lucida, lamina densa and lamina reticularis. The basal lamina, a mixture of glycoproteins and collagen, provides an attachment site for the epithelium, separating it from underlying connective tissue. The framework of basal lamina has other essential proteins such as laminins mesh, perlecan, entactin, and type IV collagen.
Proteins...
Proteins...
3.1K
02:57Targeted Cancer Therapies
7.0K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.0K
01:21Cancer Survival Analysis
863
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
863
01:05Type IV Collagen of Basal Lamina
2.5K
Type IV collagen is a 400 nm long, network-forming collagen that acts as a barrier between the epithelial and endothelial cells. Type IV collagen forms the backbone of the basement membrane by scaffolding with laminin, entactin, proteoglycans, and fibronectin. Apart from rendering structural support to the basement membrane, it also helps entail signaling potentials necessary for both pathological and physiological functions.
A type IV collagen molecule has six alpha chains which can...
A type IV collagen molecule has six alpha chains which can...
2.5K