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Related Experiment Video

Updated: May 1, 2026

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Quantification of cerebral perfusion using dynamic quantitative susceptibility mapping.

Bo Xu1, Pascal Spincemaille, Tian Liu

  • 1Department of Biomedical Engineering, Cornell University, Ithaca, New York, USA; Department of Radiology, Weill Cornell Medical College, New York, New York, USA.

Magnetic Resonance in Medicine
|April 16, 2014
PubMed
Summary
This summary is machine-generated.

Dynamic quantitative susceptibility mapping (QSM) enables 4D contrast agent mapping for brain perfusion imaging. This novel technique accurately measures cerebral blood flow, showing strong agreement with established methods.

Keywords:
cerebral blood flowcerebral blood volumecerebral perfusioncontrast agent quantificationquantitative susceptibility mappingtemporal resolution acceleration with constrained evolution reconstruction

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Area of Science:

  • Neuroimaging
  • Medical Physics
  • Radiology

Background:

  • Cerebral perfusion imaging is crucial for diagnosing neurological conditions.
  • Accurate measurement of contrast agent concentration is vital for quantitative perfusion analysis.
  • Existing techniques may lack the temporal resolution for dynamic mapping.

Purpose of the Study:

  • To develop a dynamic quantitative susceptibility mapping (QSM) technique.
  • To achieve sufficient temporal resolution for mapping contrast agent concentration.
  • To enable quantitative cerebral perfusion imaging.

Main Methods:

  • Utilized a multiecho 3D spoiled gradient echo sequence with spiral acquisition.
  • Employed 4D space-time resolved magnetic field reconstruction.
  • Applied morphology enabled dipole inversion for gadolinium concentration mapping.

Main Results:

  • Demonstrated feasibility of dynamic QSM in vivo for 4D contrast agent mapping.
  • Successfully generated 3D cerebral blood volume and flow maps.
  • Cerebral blood flow measurements showed agreement with arterial spin labeling.

Conclusions:

  • Dynamic QSM is effective for 4D contrast agent concentration mapping in contrast-enhanced MRI.
  • Perfusion parameters derived from dynamic QSM correlate well with arterial spin labeling.
  • This technique advances quantitative perfusion analysis in neuroimaging.