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Rescuing US biomedical research from its systemic flaws
Bruce Alberts1, Marc W Kirschner, Shirley Tilghman
1Department of Biophysics and Biochemistry, University of California, San Francisco, CA 94158.
Summary
The unsustainable growth in biomedical science creates a hypercompetitive environment, discouraging new talent and hindering experienced researchers. Rethinking the US biomedical research system is crucial for its long-term health.
Area of Science:
- Biomedical Science
- Research Ecosystems
- Scientific Workforce
Background:
- The assumption of perpetual rapid growth in biomedical science is flawed.
- This has led to an unsustainable and hypercompetitive academic environment.
- This system negatively impacts both prospective and established researchers.
Purpose of the Study:
- To identify the detrimental effects of the current biomedical research system.
- To advocate for a fundamental reevaluation of the US biomedical research ecosystem.
- To address the unsustainable hypercompetitiveness within the field.
Main Methods:
- Qualitative analysis of the current biomedical research landscape.
- Examination of the impact of growth assumptions on the scientific workforce.
- Review of systemic issues within the US biomedical research ecosystem.
Main Results:
- The system discourages outstanding prospective students from entering the field.
- Seasoned investigators face challenges in producing their best work.
- The current trajectory poses a risk of long-term decline in biomedical science.
Conclusions:
- Simplistic solutions are inadequate for addressing the systemic problems.
- A fundamental rethinking of the US biomedical research ecosystem is necessary.
- Addressing the unsustainable growth and hypercompetitiveness is vital for the future of biomedical science.

