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Skin Adverse Events During Dual and Triple Therapy for HCV-Related Cirrhosis
Alessandro Federico1, Dolores Sgambato1, Gaetano Cotticelli1
1Department of Clinical and Experimental Medicine, Gastroenterology Unit, Second University of Naples, Naples, Italy.
Introduction:
Dermatological adverse events are an existing concern during treatment of hepatitis C virus infection. Peginterferon/ribavirin treatment is associated with well-characterized dermatological lesions tending towards a uniform entity of dermatitis. New telaprevir- or boceprevir-based triple-therapy has led to significant improvements in sustained virological response rates, although associated with an increase in cutaneous adverse events compared peginterferon/ribavirin alone.
Case Presentation:
We report a case of a patient who discontinued telaprevir because of severe skin eruptions and who, during ribavirin and interferon treatment, after a period free of skin lesions, developed new dermatological lesions different than those experienced during telaprevir treatment.
Conclusions:
Several adverse effects are associated to anti-HCV drugs, hence appropriate skin care management and follow-up are very important. A careful anamnesis before the initiation of triple therapy is necessary to identify previous dermatological diseases that could increase skin adverse effects incidence.
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