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An update on coronary artery disease and chronic kidney disease

Baris Afsar1, Kultigin Turkmen2, Adrian Covic3

  • 1Department of Nephrology, Numune State Hospital, 42690 Konya, Turkey.

International Journal of Nephrology
|April 16, 2014
PubMed

Insights

Patients with chronic kidney disease (CKD) face a high risk of cardiovascular disease (CVD), particularly coronary artery disease (CAD). This review covers the epidemiology, pathophysiology, and clinical aspects of CAD in CKD patients.

Area of Science:

  • Nephrology
  • Cardiology
  • Internal Medicine

Background:

  • Cardiovascular diseases (CVD), especially coronary artery disease (CAD), are leading causes of death in chronic kidney disease (CKD) patients.
  • CKD is an independent risk factor for CAD, with factors like malnutrition, inflammation, and atherosclerosis contributing to heightened risk.

Purpose of the Study:

  • To review the epidemiologic, pathophysiologic, and clinical aspects of CAD in CKD patients.
  • To highlight the independent association between decreased glomerular filtration rate (GFR), proteinuria, and CAD.

Main Methods:

  • Review of classical and recent literature on CAD in CKD.
  • Analysis of epidemiologic, pathophysiologic, and clinical data.

Main Results:

  • CKD significantly increases the risk of CAD due to multiple contributing factors.
  • Reduced GFR and proteinuria are independently linked to CAD in community studies.

Conclusions:

  • CAD is a major concern in CKD management.
  • Understanding the multifaceted relationship between CKD and CAD is crucial for patient outcomes.

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