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Updated: May 1, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
Published on: December 11, 2016
Digging up the human genome: current progress in deciphering adverse drug reactions
Shih-Chi Su1, Wen-Hung Chung2, Shuen-Iu Hung3
1Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, 199 Tung-Hwa North Road, Taipei 105, Taiwan.
Genetic variants influence adverse drug reactions (ADRs). Pharmacogenomic techniques identify biomarkers for ADRs, enabling personalized medicine and improved drug safety.
Area of Science:
- Pharmacogenomics
- Genetics
- Drug Safety
Background:
- Adverse drug reactions (ADRs) pose significant clinical and economic burdens.
- Individual susceptibility to ADRs is increasingly linked to genetic variations.
- Genomic technologies offer advancements in drug safety and efficacy.
Purpose of the Study:
- To review pharmacogenomic techniques for identifying ADR determinants.
- To summarize progress in discovering ADR biomarkers, focusing on genetic variants.
- To highlight the role of pharmacogenomics in personalized medicine.
Main Methods:
- Review of pharmacogenomic techniques.
- Analysis of genetic variants in drug-metabolizing enzymes, drug transporters, and HLA genes.
- Synthesis of current research on ADR biomarker identification.
Main Results:
- Genetic variants in key genes are crucial determinants of ADR susceptibility.
- Pharmacogenomic approaches are advancing the identification of reliable ADR biomarkers.
- Identification of specific genetic biomarkers aids in predicting and managing ADRs.
Conclusions:
- Pharmacogenomics provides essential tools for understanding and mitigating ADRs.
- Biomarker discovery through genetic analysis is key to personalized drug therapy.
- Integrating pharmacogenomic findings will enhance drug safety and patient outcomes.
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