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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
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Microstructural brain changes in acromegaly: quantitative analysis by diffusion tensor imaging.

R Kilicarslan1, M M Ilhan, A Alkan

  • 11 Department of Radiology, Bezmialem Vakif University School of Medicine, Istanbul, Turkey.

The British Journal of Radiology
|April 17, 2014
PubMed
Summary
This summary is machine-generated.

Acromegaly patients show altered brain diffusion metrics, particularly in specific brain regions, regardless of disease duration or remission status. This suggests subclinical brain damage may occur early in acromegaly.

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Area of Science:

  • Neuroimaging
  • Endocrinology
  • Diffusion Tensor Imaging

Background:

  • Acromegaly, a condition caused by excess growth hormone, can lead to various neurological complications.
  • Brain diffusion changes in acromegaly patients are not fully understood, especially concerning disease duration and treatment status.

Purpose of the Study:

  • To investigate brain diffusion changes in acromegaly patients using apparent diffusion coefficient (ADC) and fractional anisotropy (FA) metrics.
  • To compare diffusion metrics between acromegaly patients in remission and those not in remission.
  • To explore the impact of hormone exposure duration on brain diffusion.

Main Methods:

  • Diffusion Tensor Imaging (DTI) was used to calculate ADC and FA values in 35 acromegaly patients and 28 controls.
  • Patients were categorized into remission and non-remission groups.
  • Statistical analyses were performed to compare diffusion metrics among groups and correlate them with disease duration.

Main Results:

  • Decreased FA and increased ADC values were observed in specific brain areas, including the hypothalamus, parietal white matter, and pre-motor cortex.
  • No significant differences in brain diffusion metrics were found between remission and non-remission groups.
  • Disease duration did not correlate with observed brain microstructural changes.

Conclusions:

  • Acromegaly patients exhibit altered brain diffusion, irrespective of disease duration or treatment status.
  • These findings suggest that subclinical brain damage may occur in acromegaly even before symptom onset.
  • This study enhances understanding of acromegaly's underlying mechanisms and potential early neurological impact.