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Related Concept Videos

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Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
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Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
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Long-Term Synaptic Plasticity in Rat Barrel Cortex.

Yong Han1, Ming-De Huang1, Man-Li Sun1

  • 1Department of Neurobiology and Physiology, Key Laboratory of Medical Neurobiology of Ministry of Health of China, Zhejiang Province Key Laboratory of Neurobiology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

Cerebral Cortex (New York, N.Y. : 1991)
|April 17, 2014
PubMed
Summary
This summary is machine-generated.

Rhythmic whisker stimulation alters sensory processing in rat brains, inducing long-lasting changes in the cerebral cortex. This plasticity is dependent on N-methyl-d-aspartate receptors and early-life whisker development.

Keywords:
barrel cortexfield potentialratssynaptic plasticityvibrissal stimulation

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Area of Science:

  • Neuroscience
  • Sensory Processing
  • Neuroplasticity

Background:

  • Rats use whisker movements for environmental exploration and object identification.
  • Neuronal activity in somatosensory pathways is influenced by whisker vibration frequency.
  • The role of rhythmic neuronal activity in cerebral sensory processing remains unclear.

Purpose of the Study:

  • To investigate the effects of rhythmic vibrissal stimulation on sensory processing in the rat cerebral cortex.
  • To elucidate the mechanisms underlying frequency-dependent, long-lasting plasticity in the somatosensory pathway.
  • To determine the developmental and receptor dependency of vibrissa-evoked plasticity.

Main Methods:

  • Rhythmic vibrissal stimulation in anesthetized rats.
  • Measurement of somatosensory-evoked potentials (SEPs) in the barrel cortex.
  • Pharmacological manipulation using dl-2-amino-5-phosphonopentanoic acid (an N-methyl-d-aspartate receptor antagonist).
  • Whisker trimming at different postnatal ages.

Main Results:

  • Rhythmic vibrissal stimulation induced frequency-dependent, long-lasting changes in SEP amplitude in the contralateral barrel cortex.
  • The observed plasticity was N-methyl-d-aspartate receptor-dependent.
  • Early-life (postnatal days 1-7) but not later (postnatal days 29-35) whisker trimming impaired long-term plasticity.
  • No long-lasting plasticity was observed in the thalamus.

Conclusions:

  • Natural rhythmic whisker activity modulates sensory information processing in the cerebral cortex.
  • Vibrissa-to-cortex long-term plasticity is dependent on N-methyl-d-aspartate receptors and critical developmental periods.
  • These findings offer insights into the mechanisms of sensory perception and learning.