Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

26.4K
Overview
26.4K
Allergic Drug Reactions01:27

Allergic Drug Reactions

1.6K
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
1.6K
Hypersensitivities01:30

Hypersensitivities

7.3K
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
7.3K
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

209
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
209
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

14.1K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
14.1K
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

280
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
280

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<i>In silico</i> prediction and IgE serum screening for potential allergenicity of novel foods-a case of fungal biomass Fermotein®.

Frontiers in allergy·2026
Same author

Women with chronic pelvic pain can be stratified using multimodal assessment.

Pain·2026
Same author

Fel d 1-Expressing Plant-Derived Bioparticle: A Novel Treatment for Cat Allergy.

Allergy·2026
Same author

Frequency and severity of 192 foods causing food allergy in adults.

The journal of allergy and clinical immunology. Global·2026
Same author

The Evolution of Sesame Seed Allergy Over Time.

Allergy·2026
Same author

Food allergy outside the eight big foods in Europe: A systematic review and meta-analysis.

Clinical and translational allergy·2026

Related Experiment Video

Updated: May 1, 2026

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
08:25

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

Published on: September 26, 2022

3.3K

Allergic sensitization: host-immune factors.

Ronald van Ree1, Lone Hummelshøj, Maud Plantinga

  • 1Departments of Experimental Immunology and Otorhinolaryngology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Room K0-130, 1105 AZ, Amsterdam, The Netherlands. r.vanree@amc.uva.nl.

Clinical and Translational Allergy
|April 17, 2014
PubMed
Summary

Allergic sensitization involves complex interactions between allergens, the environment, and the host immune system. Key immune cells like dendritic cells (DCs) and T-helper cells drive allergic inflammation, leading to IgE production.

More Related Videos

Murine Model of Epicutaneously-Induced Immunomodulation
09:07

Murine Model of Epicutaneously-Induced Immunomodulation

Published on: June 24, 2025

626
Humanized Mediator Release Assay as a Read-Out for Allergen Potency
10:22

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

4.9K

Related Experiment Videos

Last Updated: May 1, 2026

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
08:25

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

Published on: September 26, 2022

3.3K
Murine Model of Epicutaneously-Induced Immunomodulation
09:07

Murine Model of Epicutaneously-Induced Immunomodulation

Published on: June 24, 2025

626
Humanized Mediator Release Assay as a Read-Out for Allergen Potency
10:22

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

4.9K

Area of Science:

  • Immunology
  • Allergy Research
  • Epithelial Biology

Background:

  • Allergic sensitization arises from intricate interactions between allergens, host factors, and the environment.
  • The mucosal epithelial layer is the primary barrier against allergens, and its increased permeability in allergic diseases facilitates environmental triggers.
  • Epithelial cells, stimulated by allergens and co-factors via innate immune receptors, produce cytokines that promote T-helper 2 (Th2) cell responses in susceptible individuals.

Purpose of the Study:

  • To elucidate the cellular and molecular mechanisms underlying allergic sensitization.
  • To describe the role of dendritic cells (DCs) and T-helper cell subsets in driving allergic inflammation.
  • To highlight the plasticity of T-helper cell responses and their contribution to allergic diseases.

Main Methods:

  • Review of current understanding of allergic sensitization pathways.
  • Analysis of the roles of various immune cells, including epithelial cells, dendritic cells (DCs), and T-helper cells.
  • Discussion of cytokine profiles and their impact on adaptive immunity.

Main Results:

  • Dendritic cells, specifically CD11b+ conventional DCs (cDCs) and monocyte-derived DCs (moDCs), are identified as key inflammatory DCs instructing naive T cells towards a Th2 phenotype.
  • The traditional view of stable Th1/Th2 subsets is evolving to include a spectrum of T-helper cells (Th9, Th17, Th22, Treg) with plastic cytokine profiles that modulate allergic inflammation.
  • Interleukin-4 (IL-4) and/or IL-13 signaling promote IgE production by B cells, a process more efficient in youth, with long-lived IgE-producing plasma cells evading therapy.

Conclusions:

  • Allergic sensitization is a multifaceted process driven by the interplay of allergens, environmental context, and a host immune system predisposed to allergic inflammation.
  • The plasticity of T-helper cell responses and the specific signals from DCs dictate the type and intensity of allergic inflammation.
  • Understanding these complex interactions is crucial for developing targeted therapeutic strategies against allergic diseases.