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Updated: May 1, 2026

Synthesis of an In vivo MRI-detectable Apoptosis Probe
Published on: July 31, 2012
SPION-Smac mimetic nano-conjugates: putative pro-apoptotic agents in oncology
Pierfausto Seneci1, Mattia Rizzi1, Luigi Ballabio1
1Università degli Studi di Milano, Dipartimento di Chimica, Via Golgi 19, I-20133 Milan, Italy.
Abstract:
Non-covalent (NP-1/3) and covalent (NP-A-1/3) pro-apoptotic SPION-Smac mimetic nano-conjugates antitumor agents are reported. The solution synthesis of key Smac mimetics, their support onto SPIONs through non-covalent adsorption (NP-1/3) or APTES-mediated covalent binding (NP-A-1/3), the analytical characterization of SPION-Smac mimetic conjugates, their target affinity in cell-free assays, and their cytotoxicity against tumor cells are thoroughly described.
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