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Localized retinal nerve fiber layer defects and stroke.

Dandan Wang¹, Yang Li¹, Chunxue Wang¹

¹From the Department of Neurology, Beijing Tiantan Hospital (D.W., C.W., X.Z.), Beijing Tongren Eye Center, Beijing Key Laboratory of Ophthalmology and Visual Science, Beijing Tongren Hospital (Y.L., W.B.W.), and Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Key Laboratory of Ophthalmology and Visual Science, Beijing Tongren Hospital (L.X., Q.S.Y., Y.X.W., L.Z., J.B.J.), Capital Medical University, Beijing, China; and Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University, Heidelberg, Germany (J.B.J.).

|April 17, 2014

Summary

This summary is machine-generated.

Localized retinal nerve fiber layer defects (RNFLDs) are strongly linked to both acute and previous cerebrovascular stroke. Noninvasive optical coherence tomography can detect these RNFLDs, adding them as a key indicator of stroke.

Keywords:

stroke tomography, optical coherence

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Area of Science:

Ophthalmology
Neurology
Medical Imaging

Background:

The retina and brain share closely related circulatory systems.
Investigating retinal indicators for neurological conditions is crucial.

Purpose of the Study:

To determine if localized retinal nerve fiber layer defects (RNFLDs) are associated with cerebrovascular stroke.
To explore the relationship between RNFLDs and both acute and previous stroke events.

Main Methods:

Compared patients with acute ischemic stroke to participants in the population-based Beijing Eye Study.
Utilized spectral-domain optical coherence tomography (OCT) to detect localized RNFLDs in the retina.

Main Results:

Acute stroke showed a significant association with localized RNFLDs (OR, 6.23) after adjusting for risk factors.
Previous stroke was also associated with localized RNFLDs (OR, 1.48) in multivariate analysis.
Localized RNFLDs were independently associated with cerebral stroke (OR, 3.54).

Conclusions:

Localized RNFLDs demonstrate a strong association with cerebrovascular stroke, and vice versa.
Noninvasive OCT imaging of RNFLDs can be a valuable addition to identifying stroke-related morphological changes in the retina.