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Published on: July 30, 2012
Disseminated cryptococcosis
Meenakshi Bothra1, Prakash Selvaperumal, Madhulika Kabra
1Departments of Pediatrics and *Pathology, All India Institute of Medical Sciences, New Delhi, India. Correspondence to: Dr Madhulika Kabra, Additional Professor, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India. madhulikakabra@hotmail.com.
Background:
Fungal infections, especially in immunocompetent children are uncommon causes of fever of unknown origin.
Case Characteristics:
A 5-year-old boy with prolonged fever and no evidence of immunosuppression.
Observation:
Ultrasound-guided retroperitoneal lymph node biopsy showed granulomas and intracytoplamic fungal yeasts; staining charactristics were suggestive of cryptococci. Clinical and radiological improvement was seen after treatment with amphoterecin-B.
Outcome:
Disseminated fungal infection should be suspected as a cause of pyrexia of unknown origin after ruling out the commoner causes. Biopsy from enlarged lymph node or organomegaly may yield the diagnosis when non-invasive tests fail.
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