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Updated: May 1, 2026

Author Spotlight: Biological Standardization to Ensure Reproducibility and Harmonization in Research
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Author Spotlight: Biological Standardization to Ensure Reproducibility and Harmonization in Research

Published on: August 4, 2023

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Standardizing vitamin D assays: the way forward.

Neil Binkley1, Christopher T Sempos,

  • 1Osteoporosis Clinical Research Program and Institute on Aging, University of Wisconsin-Madison, Madison, WI, USA.

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
|April 17, 2014
PubMed
Summary

Accurate vitamin D status assessment requires standardized 25-hydroxyvitamin D [25(OH)D] measurements. The Vitamin D Standardization Program (VDSP) offers a solution to reduce assay variability and improve clinical guidelines.

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Area of Science:

  • Clinical Chemistry
  • Nutritional Biochemistry
  • Laboratory Medicine

Background:

  • Serum 25-hydroxyvitamin D [25(OH)D] is the standard biomarker for vitamin D status.
  • Significant variability exists between different assays for 25(OH)D measurement.
  • This variability complicates the diagnosis of vitamin D deficiency and hinders evidence synthesis.

Purpose of the Study:

  • To highlight the critical need for standardization of 25(OH)D measurements.
  • To propose the Vitamin D Standardization Program (VDSP) as a solution.
  • To facilitate the development of evidence-based clinical guidelines.

Main Methods:

  • Discussion of existing challenges in 25(OH)D assay variability.
  • Introduction of the Vitamin D Standardization Program (VDSP).
Keywords:
25-HYDROXYVITAMIN DSTANDARDIZATIONVDSPVITAMIN DVITAMIN D STANDARDIZATION PROGRAM

Related Experiment Videos

Last Updated: May 1, 2026

Author Spotlight: Biological Standardization to Ensure Reproducibility and Harmonization in Research
04:50

Author Spotlight: Biological Standardization to Ensure Reproducibility and Harmonization in Research

Published on: August 4, 2023

1.8K
  • Outline of the VDSP's approach to standardization.

    • Main Results:

    • Assay variability in 25(OH)D measurement is a significant issue.
    • Standardization is essential for accurate diagnosis and research synthesis.
    • The VDSP provides a framework for achieving measurement standardization.

    Conclusions:

    • Standardizing 25(OH)D measurements is crucial for clinical practice and research.
    • The VDSP offers a viable pathway to achieve reliable vitamin D status assessment.
    • Implementation of the VDSP will improve the quality of vitamin D-related guidelines.