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Updated: May 1, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Synthesis of new thiobarbituric acid derived spiroheterobicyclic compounds and their antimicrobial activity
Gurpreet Kaur1, Parul Gupta, Kusum Harjai
1Department of Applied Sciences, PEC University of Technology, Chandigarh, 160012, India.
Abstract:
A series pf novel (7S, 11R)-substituted diphenyl-2,4,8,10-tetraazaspiro [5.5] undecane-3-thio-1,5,9-triones 4a-j and (7S,11R)-substituted diphenyl-2,4,8,10-tetraazaspiro[5.5] undecane-3-thio-1,5 dione, 9-thiones 5a-j were prepared using substituted aldehydes and urea/thiourea in the presence of thiobarbituric acid under solvent free, thermal and microwave conditions catalyzed by ecofriendly K-10 clay. The antibacterial potency of these compounds in vitro on the gram negative strains Escherichia coli and Pseudomonas aeruginosa and gram positive strains Staphyllococcus aureus and Staphylococcus epidermidis was evaluated.
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