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Related Experiment Video

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TRASER: acute phase vascular and follicular changes.

Katharine Ball1, Morgan Gustavsson, Ronald Harris

  • 1Department of Dermatology, University of California Irvine, Irvine, California.

Lasers in Surgery and Medicine
|April 17, 2014
PubMed
Summary

This study demonstrates the effectiveness of the Total Reflection Amplification of Spontaneous Emission of Radiation (TRASER) device for vascular and hair removal. The TRASER shows promising clinical and histological results for targeted skin treatments.

Keywords:
TRASERhair removalhistologyvascular lesion

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Area of Science:

  • Dermatology
  • Aesthetic Medicine
  • Biophotonics

Background:

  • A novel Total Reflection Amplification of Spontaneous Emission of Radiation (TRASER) device uses flashlamp energy to induce photon emission from fluorescent media.
  • This study investigates the clinical and histological effects of TRASER using media tuned for vascular and hair follicle targets.

Purpose of the Study:

  • To observe and document the clinical and histological changes in skin treated with two distinct TRASER fluorescent media.
  • To evaluate the efficacy of TRASER for targeting vascular and hair follicle structures.

Main Methods:

  • Vascular targets were treated with Pyrromethene 556 (peak emission 544 nm) on forearm skin (photo type II).
  • Hair follicle targets were treated with Sulforhodamine 640 Chloride (peak emission 654 nm) on chest skin (photo type II, brown hair) with contact cooling.
  • Clinical assessments and 4 mm punch biopsies were performed for histological analysis.

Main Results:

  • A threshold purpuric response for vascular treatment was observed at 7.2 J/cm2, with histological evidence of intravascular thrombosis in capillaries and small vessels.
  • No extravasated red blood cells were noted in vascular treatments.
  • Hair follicle treatments showed perifollicular edema and transient erythema, histologically limited to the target structures.

Conclusions:

  • This study presents the first clinical and histological evidence of acute changes from TRASER use with optimized wavelengths for vascular and follicular targets.
  • The findings support the TRASER's potential as an effective device for vascular and hair removal applications.