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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

15.4K

Chronic kidney disease stage is a modulator on the association between high-sensitivity C-reactive protein and

Heng-Jung Hsu1, Chiung-Hui Yen2, Kuang-Hung Hsu3

  • 1Department of Nephrology, Chang Gung Memorial Hospital, Keelung 20401, Taiwan ; The Graduate Institute of Clinical Medical Sciences, Chang Gung University Medical College, Taoyuan 33302, Taiwan ; Department of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.

Thescientificworldjournal
|April 17, 2014
PubMed

Insights

Coronary vasospasm in chronic kidney disease (CKD) is linked to monocyte count in all stages. High-sensitivity C-reactive protein (hs-CRP) is associated only in stage 1 CKD.

Area of Science:

  • Nephrology
  • Cardiology
  • Immunology

Background:

  • Coronary vasospasm prevalence and associated factors in chronic kidney disease (CKD) remain unclear.
  • CKD is a significant risk factor for cardiovascular diseases, including coronary artery disease.
  • Angina pectoris is a common symptom in CKD patients, often requiring investigation for underlying causes like vasospasm.

Purpose of the Study:

  • To investigate the prevalence of coronary vasospasm in CKD patients presenting with angina pectoris.
  • To identify clinical and laboratory factors associated with coronary vasospasm in CKD patients.
  • To determine the independent predictors of coronary vasospasm across different stages of CKD.

Main Methods:

  • Cross-sectional study involving 859 consecutive CKD patients with angina pectoris undergoing coronary catheterization.
  • Comparison of clinical characteristics and laboratory findings between patients with and without coronary vasospasm.
  • Multivariate logistic regression analysis to identify independent factors associated with coronary vasospasm.

Main Results:

  • Patients with vasospasm were older and exhibited higher peripheral white blood cell counts, monocyte counts, hemoglobin levels, and hs-CRP levels, along with lower serum creatinine levels.
  • Peripheral blood monocyte count and hs-CRP level were independently associated with coronary vasospasm in stage 1 CKD.
  • Peripheral blood monocyte count was independently associated with coronary vasospasm in stages 2 and 3 CKD, but hs-CRP was not.

Conclusions:

  • Peripheral blood monocyte count is an independent predictor of coronary vasospasm in patients with stages 1-3 CKD.
  • High-sensitivity C-reactive protein (hs-CRP) is independently associated with coronary vasospasm specifically in stage 1 CKD patients.
  • These findings highlight the role of inflammation and specific immune cell counts in the pathophysiology of coronary vasospasm in the context of CKD.

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