Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Vascular Resistance01:20

Vascular Resistance

14.2K
Vascular resistance is a critical concept in understanding blood flow dynamics in the circulatory system. It refers to the resistance that blood encounters as it flows through the blood vessels. This resistance is a key factor in determining blood pressure and cardiac workload.
The primary determinants of vascular resistance are vessel diameter, blood viscosity, and vessel length. Among these, vessel diameter plays the most significant role due to the fourth power relationship described by...
14.2K
Disorders of the Autonomic Nervous System01:18

Disorders of the Autonomic Nervous System

1.9K
The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's...
1.9K
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

1.8K
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.8K
Cardiovascular Drugs: Classification based on Therapeutic Indications01:18

Cardiovascular Drugs: Classification based on Therapeutic Indications

4.2K
Cardiovascular diseases, encompassing a range of conditions, can significantly affect the heart's operations and the overall circulatory system. These conditions impair the heart's ability to pump blood, leading to a deficit in oxygen supply to crucial organs. Anomalies in the heart's electrical system, known as arrhythmias, can cause heartbeats to accelerate or slow down. Usually, heart rates increase during physical activity and decrease while resting or sleeping. However,...
4.2K
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

757
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
757
Antihypertensive Drugs: Vasodilators01:23

Antihypertensive Drugs: Vasodilators

2.5K
Vasodilators, primarily affecting the smooth muscles within arterial and venous walls, are commonly used for hypertension treatment. Medications such as minoxidil and hydralazine primarily target arteries and arterioles, while sodium nitroprusside acts on arterioles and venules. Minoxidil, functioning as a prodrug, is metabolized by hepatic sulfotransferase into its active form, minoxidil sulfate, after oral administration. This metabolite binds to the sulfonylurea receptor (SUR) component of...
2.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Beneficial vascular effects of oral phosphatidylserine supplementation in type 2 diabetes.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same author

Molecular Mechanisms of Endothelial Shear Stress Mechanotransduction in Health and Disease.

Handbook of experimental pharmacology·2026
Same author

It cannot be that suddenly all research is more transformative and produces greater insights: the influence of AI on scientific writing.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same author

Muscular Fitness Components in Adults With Type 1 Diabetes: A Cross-Sectional Study.

Diabetes/metabolism research and reviews·2026
Same author

Endothelial CD44 cleavage by ADAM17 impairs shear stress mechanotransduction.

Function (Oxford, England)·2026
Same author

Lack of endothelial estrogen receptor alpha signaling exacerbates abdominal aortic aneurysm in male mice.

American journal of physiology. Heart and circulatory physiology·2026

Related Experiment Video

Updated: May 1, 2026

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
06:04

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome

Published on: September 27, 2024

1.7K

Delayed vasodilation is associated with cardiovascular risk.

Concetta Irace1, Jaume Padilla, Claudio Carallo

  • 1Department of Clinical and Experimental Medicine, University Magna Graecia, Catanzaro, Italy.

European Journal of Clinical Investigation
|April 18, 2014
PubMed
Summary

Assessing cardiovascular risk involves evaluating flow-mediated dilation (FMD) kinetics. Delayed vasodilation, even with significant FMD, indicates higher risk, suggesting both FMD magnitude and timing are crucial for risk assessment.

Keywords:
Atherosclerosiscardiovascular riskcardiovascular risk factorsflow-mediated dilationultrasound

More Related Videos

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000
07:46

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000

Published on: October 15, 2010

45.2K
Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research
08:42

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research

Published on: October 22, 2014

26.8K

Related Experiment Videos

Last Updated: May 1, 2026

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
06:04

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome

Published on: September 27, 2024

1.7K
Assessing Endothelial Vasodilator Function with the Endo-PAT 2000
07:46

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000

Published on: October 15, 2010

45.2K
Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research
08:42

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research

Published on: October 22, 2014

26.8K

Area of Science:

  • Cardiovascular physiology
  • Endothelial function assessment
  • Vascular reactivity

Background:

  • Flow-mediated dilation (FMD) of the brachial artery is a standard method for cardiovascular risk assessment.
  • Recent research emphasizes the kinetics of vasodilation to better understand endothelial function.
  • This study explores the relationship between FMD characteristics and individual cardiovascular risk.

Purpose of the Study:

  • To determine whether the magnitude or latency of flow-mediated dilation (FMD) is more closely associated with individual cardiovascular risk.
  • To investigate the combined impact of FMD magnitude and timing on cardiovascular risk stratification.

Main Methods:

  • Recruited 400 subjects for cardiovascular risk assessment.
  • Utilized Framingham cardiovascular risk score and CUORE project calculator for risk prediction.
  • Categorized subjects into Early dilators (peak FMD at 50s), Late dilators (peak FMD >50s), and No dilators based on FMD response time.

Main Results:

  • Cardiovascular risk was highest in 'No dilators' and significantly greater in 'Late dilators' compared to 'Early dilators', even with similar peak FMD.
  • Increasing FMD magnitude correlated with decreased cardiovascular risk across both Early and Late dilators.
  • Late dilators within the lower three peak FMD quintiles exhibited higher risk scores than Early dilators with comparable vasodilation.

Conclusions:

  • Both the magnitude and latency of flow-mediated dilation (FMD) are significant indicators for identifying patients at risk of cardiovascular disease.
  • Individuals with delayed vasodilation, particularly those with a blunted early response, present the highest cardiovascular risk.
  • FMD kinetics, beyond peak dilation, provides critical information for comprehensive cardiovascular risk assessment.