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Efficient synthesis of 1,5-disubstituted carbohydrazones using K₂CO₃ as a carbonyl donor
Jun Wen1, Chu-Ting Yang, Tao Jiang
1Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics , Mianyang 621900, Sichuan Province, China.
Abstract:
A novel reaction that generates 1,5-disubstituted carbohydrazones via the carbonylation of tosylhydrazones has been developed. For the first time, the inexpensive, readily available, environmentally friendly, and nongaseous potassium carbonate is used as the carbonyl donor for the transformation. The reaction system exhibited tolerance with various functional groups and affords the desired products in good to excellent yields. This reaction is expected to be a powerful tool for the synthesis of carbohydrazone compounds.
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