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Dextran protection of erythrocytes from low-pH-induced hemolysis
1Biophor Corporation, Texas A & M University Research Park, College Station 77840.
FEBS Letters
|July 3, 1989
Abstract:
Low-pH-induced hemolysis of erythrocytes is inhibited by dextrans. The protective effect was observed with dextrans larger than 40 kDa. Electron microscopy showed dextrans of 150 kDa in a tight association with the erythrocyte membrane. These results indicate that dextrans stop the low-pH-induced hemolysis by interacting with the acid-induced defects in the erythrocyte membrane [(1989) Biochim. Biophys. Acta, in press].