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Related Experiment Videos

A chicken homeo box gene with developmentally regulated expression.

A Fainsod1, Y Greunbaum

  • 1Department of Cellular Biochemistry, Hebrew University-Hadassah Medical School, Jerusalem, Israel.

FEBS Letters
|July 3, 1989
PubMed
Summary

Researchers identified a chicken homeobox gene, CHox7, related to the Antp class. Its gene expression shows distinct transcript patterns during key embryonic developmental stages in chickens.

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Area of Science:

  • Developmental Biology
  • Genomics
  • Molecular Biology

Background:

  • Homeobox genes are crucial regulators of embryonic development.
  • Understanding homeobox gene evolution and function provides insights into conserved developmental pathways.

Purpose of the Study:

  • To isolate and characterize homeobox sequences from the chicken genome.
  • To investigate the expression patterns of a novel chicken homeobox gene (CHox7) during embryogenesis.

Main Methods:

  • Screening of a chicken genomic library using homeobox probes.
  • DNA sequencing and sequence analysis of isolated homeobox genes.
  • Analysis of CHox7 gene transcript accumulation during chicken embryogenesis via transcript size determination.

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Main Results:

  • Isolation of several homeobox sequences, including one from phage lambda GG7, designated CHox7.
  • CHox7 sequence analysis revealed it as a distant member of the Antennapedia (Antp) class of homeoboxes.
  • CHox7 expression produces four transcripts (1.4, 1.9, 2.4, and 3.5 kb) with peak accumulation during early somitogenesis and organogenesis stages of embryogenesis.

Conclusions:

  • CHox7 represents a novel chicken homeobox gene with evolutionary links to the Antp class.
  • The distinct temporal expression patterns of CHox7 transcripts suggest specific roles during critical phases of chicken embryonic development, including somitogenesis and organogenesis.