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Caldesmon150, caldesmon77 and skeletal muscle troponin T share a common antigenic determinant
V P Shirinsky1, K G Biryukov, A V Vorotnikov
1Institute of Experimental Cardiology, USSR Cardiology Research Center, USSR Academy of Medical Sciences, Moscow.
FEBS Letters
|July 17, 1989
Abstract:
Caldesmon and troponin are known to control actin-myosin interaction in smooth and striated muscle. We showed that polyclonal antibodies to smooth muscle caldesmon150 cross-react with non-muscle caldesmon77 and with skeletal muscle troponin T. The epitope recognized by caldesmon antibodies is located in the CB 2 peptide [residues 71-151] of troponin T. It is supposed that the observed cross-reactivity is due to the common structure of the tropomyosin-binding site of caldesmon and troponin T.